Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Iadademstat dihydrochloride (ORY-1001(trans)) 是一种不可逆的选择性赖氨酸特异性脱甲基酶 1A(KDM1A/LSD1) 抑制剂,用于治疗急性白血病。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 546 | 现货 | ||
5 mg | ¥ 1,250 | 现货 | ||
10 mg | ¥ 1,920 | 现货 | ||
25 mg | ¥ 3,890 | 现货 | ||
50 mg | ¥ 5,570 | 现货 | ||
100 mg | ¥ 7,790 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,390 | 现货 |
产品描述 | Iadademstat dihydrochloride (ORY-1001(trans)) , a Potent and Selective Covalent KDM1A/LSD1 Inhibitor, for the Treatment of Acute Leukemia. |
体外活性 | ORY-1001 is a highly potent and selective KDM1A inhibitor that induces H3K4me2 accumulation on KDM1A target genes, blast differentiation, and reduction of leukemic stem cell capacity in AML. |
体内活性 | ORY-1001 exhibits potent synergy with standard-of-care drugs and selective epigenetic inhibitors, reduces growth of an AML xenograft model, and extends survival in a mouse PDX (patient-derived xenograft) model of T cell acute leukemia.?Surrogate pharmacodynamic biomarkers developed based on expression changes in leukemia cell lines were translated to samples from patients treated with ORY-1001.?ORY-1001 is a selective KDM1A inhibitor in clinical trials and is currently being evaluated in patients with leukemia and solid tumors. |
别名 | ORY-1001(trans) |
分子量 | 303.27 |
分子式 | C15H24Cl2N2 |
CAS No. | 1431303-72-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 3.03 mg/mL (10 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.2974 mL | 16.487 mL | 32.9739 mL | 82.4348 mL |
5 mM | 0.6595 mL | 3.2974 mL | 6.5948 mL | 16.487 mL | |
10 mM | 0.3297 mL | 1.6487 mL | 3.2974 mL | 8.2435 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Iadademstat dihydrochloride 1431303-72-8 Chromatin/Epigenetic Histone Demethylase RO 7051790 RG 6016 RO7051790 inhibit RG6016 Inhibitor ORY1001 RO-7051790 ORY 1001 Iadademstat Dihydrochloride ORY-1001 Iadademstat RG-6016 ORY-1001(trans) inhibitor